Risk of tumorigenicity in mesenchymal stromal cell-based therapies--bridging scientific observations and regulatory viewpoints.
Barkholt L, Flory E, Jekerle V, Lucas-Samuel S, Ahnert P, Bisset L, Büscher D, Fibbe W, Foussat A, Kwa M, Lantz O, Mačiulaitis R, Palomäki T, Schneider CK, Sensebé L, Tachdjian G, Tarte K, Tosca L, Salmikangas P.
Cytotherapy, 2013, 15(7):753-9. doi: 10.1016/j.jcyt.2013.03.005
Barkholt et al. 2013.pdf
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Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue.
Deschaseaux F, Gaillard J, Langonné A, Chauveau C, Naji A, Bouacida A, Rosset P, Heymann D, De Pinieux G, Rouas-Freiss N, Sensébé L.
FASEB J. 2013, 27(8):2977-87. doi: 10.1096/fj.13-227264
Donor selection and release criteria of cellular therapy products.
Eichler H, Schrezenmeier H, Schallmoser K, Strunk D, Nystedt J, Kaartinen T, Korhonen M, Fleury-Cappellesso S, Sensebé L, Bönig H, Rebulla P, Giodano R, Lecchi L, Takanashi M, Watt SM, Austin EB,
Guttridge M, Mc Laughlin LS, Panzer S, Reesink HW.
Vox Sang. 2013;104:67-91. doi: 10.1111/j.1423-0410.2012.01619.x.
Sox9-regulated miRNA-574-3p inhibits chondrogenic differentiation of mesenchymal stem cells.
Guérit D, Philipot D, Chuchana P, Toupet K, Brondello JM, Mathieu M, Jorgensen C and Noël D.
PLoS ONE, 2013, 23;8(4):e62582. doi: 10.1371/journal.pone.0062582.
Guérit et al. 2013.pdf
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Immunological characterization of multipotent mesenchymal stromal cells--The International Society for Cellular Therapy (ISCT) working proposal.
Krampera, M., Galipeau, J., Shi, Y., Tarte, K., Sensebe, L., and MSC Committee of the International Society for Cellular Therapy (ISCT) Cytotherapy, 2013, 15(9):1054-61. doi: 10.1016/j.jcyt.2013.02.010
Krampera et al. 2013.pdf
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139.6 KB
Platelet lysate coating on scaffolds directly and indirectly enhances cell migration, improving bone and blood vessel formation.
Leotot J, Coquelin L, Bodivit G, Bierling P, Hernigou P, Rouard H, Chevallier N.
Acta Biomater. 2013, 9(5):6630-40. doi: 10.1016/j.actbio.2013.02.003
Leotot et al. 2013.pdf
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1.2 MB
Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion.
Lopez-Mejia IC, De Toledo M, Della Seta F, Fafet P, Rebouissou C, Deleuze V, Blanchard JM, Jorgensen C, Tazi J and Vignais ML.
Mol. Biol. Cell, 2013, 24(20):3164-76. doi: 10.1091/mbc.E13-03-0142
Lopez-Meija et al. 2013.pdf
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5.8 MB
Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells.
Luz-Crawford P, Kurte M, Bravo-Alegría J, Contreras R, Nova-Lamperti E, Tejedor G, Noël D, Jorgensen C, Figueroa F, Djouad F and Carrion F. Stem Cell Res Ther, 2013, 4;4(3):65. doi: 10.1186/scrt216
Luz-Crawford et al. 2013.pdf
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4.1 MB
Adipose-derived mesenchymal stem cells exert anti-inflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2.
Manferdini C, Maumus M, Gabusi E, Piacentini A, Filardo G, Peyrafitte JA, Jorgensen C, Bourin P, Fleury-Cappellesso S, Facchini A, Noël D, Lisignoli G.
Arthritis Rhum. 2013; 65:1271-1281
Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis.
Maumus M, Manferdini C, Toupet K, Peyrafitte JA, Ferreira R, Facchini A, Gabusi E, Bourin P, Jorgensen C, Lisignoli G and Noël D.
Stem Cell Res, 2013a, 11(2):834-44. doi: 10.1016/j.scr.2013.05.008
Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes. Maumus M, Jorgensen C and Noël D.
Biochimie, 2013b, 95(12):2229-34. doi: 10.1016/j.biochi.2013.04.017
Clinical-grade mesenchymal stromal cells produced under various good manufacturing practice processes differ in their immunomodulatory properties: standardization of immune quality controls.
Menard C, Pacelli L, Bassi G, Dulong J, Bifari F, Bezier I, Zanoncello J, Ricciardi M, Latour M, Bourin P, Schrezenmeier H, Sensebé L, Tarte K, Krampera M.
Stem Cells Dev, 2013, 15;22(12):1789-801. doi: 10.1089/scd.2012.0594.
Bourin et al. 2013.pdf
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653.0 KB
Concise review: combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy.
Naji, A., Rouas-Freiss, N., Durrbach, A., Carosella, E.D., Sensébé, L., and Deschaseaux, F.
Stem Cells, 2013, 31(11):2296-303. doi: 10.1002/stem.1494
Mesenchymal Stromal Cells: Updates and Therapeutic Outlook in Rheumatic Diseases.
Pers YM, Jorgensen C.
J Clin Med. 2013, 23;2(4):201-13. doi: 10.3390/jcm2040201
Pers et al. 2013.pdf
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441.3 KB
Mesenchymal stromal cells: misconceptions and evolving concepts.
Phinney DG and Sensebé L.
Cytotherapy, 2013, 15(2):140-5. doi: 10.1016/j.jcyt.2012.11.005
MSCs: science and trials.
Phinney DG, Galipeau J, Krampera M, Martin I, Shi Y and Sensebe L.
Nat. Med, 2013, 19(7):812. doi: 10.1038/nm.3220
Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis.
Présumey J, Courties G, Louis-Plence P, Escriou V, Scherman D, Pers YM, Yssel H, Pène J, Kyburz D, Gay S, Jorgensen C and Apparailly F.
Ann. Rheum. Dis, 2013, 72(10):1717-24. doi: 10.1136/annrheumdis-2012-202403
GMP-compliant isolation and expansion of bone marrow-derived MSCs in the closed, automated device quantum cell expansion system.
Rojewski MT, Fekete N, Baila S, Nguyen K, Fürst D, Antwiler D, Dausend J, Kreja L, Ignatius A, Sensebé Land Schrezenmeier H.
Cell Transplant, 2013, 22(11):1981-2000. doi: 10.3727/096368912X657990
Rojewski et al. 2013.pdf
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800.8 KB
Beyond genetic stability of mesenchymal stromal cells.
Sensebé L.
Cytotherapy, 2013, 15(11):1307-8. doi: 10.1016/j.jcyt.2013.09.001.
Biodistribution of mesenchymal stem/stromal cells in a preclinical setting.
Sensebé L and Fleury-Cappellesso S.
Stem Cells Int, 2013, 2013:678063. doi: 10.1155/2013/678063
Sensebé et al. 2013.pdf
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482.0 KB
Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review.
Sensebé L, Gadelorge M and Fleury-Cappellesso S.
Stem Cell Res Ther, 2013, 7;4(3):66. doi: 10.1186/scrt217
Sensebé et al. 2013b.pdf
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213.5 KB
Long-term detection of human adipose-derived mesenchymal stem cells after intraarticular injection in SCID mice. Toupet K, Maumus M, Peyrafitte JA, Bourin P, van Lent PLEM,
Ferreira R, Orsetti B, Pirot N, Casteilla L, Jorgensen C and Noël D.
Arthritis Rheum, 2013, 65(7):1786-94. doi: 10.1002/art.37960
CD200R/CD200 inhibits osteoclastogenesis: new mechanism of osteoclast control by mesenchymal stem cells in human
Varin A, Pontikoglou C, Labat E, Deschaseaux F and Sensebé L.
PLoS ONE, 2013, 5;8(8):e72831. doi: 10.1371/journal.pone.0072831
Varin et al. 2013.pdf
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2.3 MB
Long-term detection of human adipose-derived mesenchymal stem cells after intraarticular injection in SCID mice.
Toupet K, Maumus M, Peyrafitte JA, Bourin P, van Lent PLEM, Ferreira R, Orsetti B, Pirot N, Casteilla L, Jorgensen C and Noël D.
Arthritis Rheum, 2013, 65(7):1786-94. doi: 10.1002/art.37960
Toupet et al. 2013.pdf
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487.5 KB
CD200R/CD200 inhibits osteoclastogenesis: new mechanism of osteoclast control by mesenchymal stem cells in human
Varin A, Pontikoglou C, Labat E, Deschaseaux F and Sensebé L.
PLoS ONE, 2013, 5;8(8):e72831. doi: 10.1371/journal.pone.0072831
Varin et al. 2013.pdf
Adobe Acrobat Document
2.3 MB
Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells
Luz-Crawford P, Kurte M, Bravo-Alegría J, Contreras R, Nova-Lamperti E, Tejedor G, Noël D, Jorgensen C, Figueroa F, Djouad F and Carrion F. Stem Cell Res Ther, 2013, 4;4(3):65. doi: 10.1186/scrt216
Luz-Crawford et al. 2013.pdf
Adobe Acrobat Document
2.7 MB
Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2
Manferdini C, Maumus M, Gabusi E, Piacentini A, Filardo G, Peyrafitte JA, Jorgensen C, Bourin P, Fleury-Cappellesso S, Facchini A, Noël D, Lisignoli G.
Arthritis Rhum. 2013; 65:1271-1281.
Manferdini et al. 2013.pdf
Adobe Acrobat Document
814.0 KB
Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis
Maumus M, Manferdini C, Toupet K, Peyrafitte JA, Ferreira R, Facchini A, Gabusi E, Bourin P, Jorgensen C, Lisignoli G and Noel D.
Stem Cell Res, 2013a, 11(2):834-44. doi: 10.1016/j.scr.2013.05.008
Maumus et al. 2013a.pdf
Adobe Acrobat Document
965.2 KB
Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes
Maumus M, Jorgensen C and Noël D.
Biochimie, 2013b, 95(12):2229-34. doi: 10.1016/j.biochi.2013.04.017
Maumus et al. 2013b.pdf
Adobe Acrobat Document
797.1 KB
Clinical-grade mesenchymal stromal cells produced under various good manufacturing practice processes differ in their immunomodulatory properties: standardization of immune quality controls
Ménard C, Pacelli L, Bassi G, Dulong J, Bifari F, Bezier I, Zanoncello J, Ricciardi M, Latour M, Bourin P, Schrezenmeier H, Sensebé L, Tarte K and Kamprera M.
Stem Cells Dev, 2013, 15;22(12):1789-801. doi: 10.1089/scd.2012.0594K
Ménard et al. 2013.pdf
Adobe Acrobat Document
649.0 KB
Concise review: combining human leukocyte antigen G and mesenchymal stem cells for immunosuppressant biotherapy
Naji A, Rouas-Freiss N, Durrbach A, Carosella ED, Sensébé L and Deschaseaux F.
Stem Cells, 2013, 31(11):2296-303. doi: 10.1002/stem.1494
Naji et al. 2013.pdf
Adobe Acrobat Document
969.7 KB
Mesenchymal Stromal Cells: Updates and Therapeutic Outlook in Rheumatic Diseases
Pers YM and Jorgensen C.
J Clin Med. 2013, 23;2(4):201-13. doi: 10.3390/jcm2040201
Pers et al. 2013.pdf
Adobe Acrobat Document
441.3 KB
Mesenchymal stromal cells: misconceptions and evolving concepts
Phinney DG and Sensebé L.
Cytotherapy, 2013, 15(2):140-5. doi: 10.1016/j.jcyt.2012.11.005
Phinney et al. 2013a.pdf
Adobe Acrobat Document
211.9 KB
MSCs: science and trials
Phinney DG, Galipeau J, Krampera M, Martin I, Shi Y and Sensebé L.
Nat. Med, 2013, 19(7):812. doi: 10.1038/nm.3220
Phinney et al. 2013b.pdf
Adobe Acrobat Document
115.2 KB
Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis
Présumey J, Courties G, Louis-Plence P, Escriou V, Scherman D, Pers YM, Yssel H, Pène J, Kyburz D, Gay S, Jorgensen C and Apparailly F.
Ann. Rheum. Dis, 2013, 72(10):1717-24. doi: 10.1136/annrheumdis-2012-202403
Présumey et al. 2013.pdf
Adobe Acrobat Document
828.2 KB
GMP-compliant isolation and expansion of bone marrow-derived MSCs in the closed, automated device quantum cell expansion system
Rojewski MT, Fekete N, Baila S, Nguyen K, Fürst D, Antwiler D, Dausend J, Kreja L, Ignatius A, Sensebé L and Schrezenmeier H.
Cell Transplant, 2013, 22(11):1981-2000. doi: 10.3727/096368912X657990
Rojewski et al. 2013.pdf
Adobe Acrobat Document
800.8 KB
Beyond genetic stability of mesenchymal stromal cells
Sensebé L.
Cytotherapy, 2013, 15(11):1307-8. doi: 10.1016/j.jcyt.2013.09.001
Sensebé 2013a.pdf
Adobe Acrobat Document
68.3 KB
Biodistribution of mesenchymal stem/stromal cells in a preclinical setting
Sensebé L and Fleury-Cappellesso S.
Stem Cells Int, 2013, 2013:678063. doi: 10.1155/2013/678063
Sensebé et al. 2013b.pdf
Adobe Acrobat Document
482.0 KB
Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review
Sensebé L, Gadelorge M and Fleury-Cappellesso S.
Stem Cell Res Ther, 2013, 7;4(3):66. doi: 10.1186/scrt217
Sensebé et al. 2013c.pdf
Adobe Acrobat Document
213.5 KB
Long-term detection of human adipose-derived mesenchymal stem cells after intraarticular injection in SCID mice
Toupet K, Maumus M, Peyrafitte JA, Bourin P, van Lent PLEM, Ferreira R, Orsetti B, Pirot N, Casteilla L, Jorgensen C and Noel D.
Arthritis Rheum, 2013, 65(7):1786-94. doi: 10.1002/art.37960
Toupet et al. 2013.pdf
Adobe Acrobat Document
487.5 KB
CD200R/CD200 inhibits osteoclastogenesis: new mechanism of osteoclast control by mesenchymal stem cells in human
Varin A, Pontikoglou C, Labat E, Deschaseaux F and Sensebé L.
PLoS ONE, 2013, 5;8(8):e72831. doi: 10.1371/journal.pone.0072831
Varin et al. 2013.pdf
Adobe Acrobat Document
2.3 MB
