As Mesenchymal stem cells (MSC) have important immunomodulating properties, it is essential to follow their impact on immune cells after treatment of patients as required by the regulatory authorities. For this purpose, ECellFrance has set up 2 state-of-the-art immunomonitoring platforms, in Rennes and Montpellier, which characterize and monitor the effect of MSC on immune cells phenotype and function.
ECellFrance’s immunomonitoring platforms provide clinical investigators with a completely standardized process, including the logistics from the sample collection and transport to the flow
cytometry experiments, analysis, reporting, and the freezing of plasma and mononuclear cells for further functional characterization. The capacity and organization of the platforms enables to
monitor large cohorts of patients treated by MSC in France and in Europe
(see ECF-clinical trials).
ECellFrance offers two levels of immunomonitoring (level 1 or 2) based on the therapeutic applications and the aims of the project. Level 1 and 2 key features are summarized below. Customized assays may also be implemented when appropriate. The levels and options are discussed with the project carrier(s) (academics or industrials) following their application to access ECellFrance’s services.
Choice between two immunomonitoring packs (level 1 or 2)
Requests for support (service provision or research agreement) can be submitted by filling the online submission form.