With its significant contributions in over 20 national and European clinical trial programs using mesenchymal stem cells (MSC), ECellFrance has acquired a large amount of data, experience, models, and tools specific to preclinical study of MSC-based products.

The preclinical platforms gather the knowhow, data and tools for biodistribution and toxicology studies specific to MSC. They are located in Montpellier, Toulouse, Clamart, and Grenoble. Each platform has its specificities in terms of equipments and fields of expertise to address, altogether, a wide range of possible applications.

Validated animal models

  • Osteo-articular and autoimmune (Montpellier)
    • arthritis (CIA/AIA/Ab-induced mouse)
    • osteoarthristis (CIOA/DMM mouse)
    • scleroderma (HOCl mouse)
    • colitis (TH cells, Rag-/- mouse)
    • delayed hypersensitivity (OVA induced DTH mouse)
  • Cadiovascular disease (Toulouse)
    • lower limb ischemia mouse model
  • Dermatology, skin wound and burns (Clamart)
    • NOD/SCID mouse model of skin wound
    • nude rat model of skin thermal burn
    • mini-pig model of radio-induced burn
  • Neurology (Grenoble)
    • Ischemic cerebrovascular model
    • Brain tumor model
    • Head trauma model
    • Epilepsy (rat and mouse model)

Evaluation administration routes, clinical and histological monitoring in animals

  • clinical response, pain assessment
  • biochemical, immunological and histological analysis
  • quantitative analysis by medical imaging (MRI, high resolution X-ray microtomography for small animal, confocal laser scanning microscopy,…)
  • regenerative potential analysis
  • macroscopic analysis
  • Immunohistological analysis

GLP accreditation for biodistribution and toxicology studies

Data on biodistribution and pharmacokinetic studies

Using GLP grade bone-marrow or adipose tissue-derived MSC, after local or systemic injection in immunodeficient mice (list of available pharmacokinetics and toxicology data).

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